Jennifer Aniston named People's 'most beautiful' woman
Aniston, 47, said she was "very, very flattered" to be named again, telling the magazine she had a "sort of very excited, teenage-y kind of moment" when she heard the news.
People also named the "Friends" star the most beautiful woman in 2004 when the TV comedy series was in its final season.
Recent winners of the honor include Sandra Bullock, Jennifer Lopez and Lupita Nyong'o.
Aniston, who last year married her second husband, actor Justin Theroux, said she started paying attention to her looks and her body early in her career after an agent told her she failed to get a part because she was "too chubby."
"I was like, 'What?!' But my diet was terrible," she said. "Milk shakes and French fries with gravy. It was a good thing to start paying attention."
Aniston now works out at least six days a week but says she is not as strict as she once was when indulging in some of her favorite foods.